جداسازی و اندازه گیری داروی الانزاپین با استفاده از پلیمرهای قالب مولکولی

abstract in this study, we synthesized a novel template polymer by using methacrylic acid (mma) as functional monomer, ethylene glycol dimethacrylate(egdma) as cross linker, 2,2-azobisisobutyronitrile (aibn) as initiator and olanzapine as targeted molecule in the presence of chloroform and acetonitrile as solvent. the products have been characterized and confirmed by (chn)elemental analysis, fourier transform infrared spectroscopy (ftir) and scanning electron microscopy (sem). in this work, we optimized variety of parameters such as the best ratio of monomer to targeted molecule, appropriate solvent for the synthesis, ph, density, resin capacity, resin saturation time, resin selectivity and desorption solvent. finally, we get advantage of the template polymer as adsorbent for extraction of olanzapine from biological fluids.